沈锡辉

沈锡辉，教授、博士生导师，获国家杰出青年科学基金项目支持(2017)，入选“万人计划”(2019)和科技部中青年科技创新领军人才推进计划(2018)。主要研究方向为微生物-环境-宿主相互作用，在细菌六型分泌系统的离子转运新功能研究、微生物信号感知机制、细菌生物膜形成及运动性调控等方面取得了比较突出的进展，以通讯作者在Nature Communications、PNAS、Cell Reports、PLoS Pathogens、mBio等国际著名期刊发表SCI论文50余篇，获授权专利5件。兼任中国微生物学会普通微生物专业委员会副主任，中国遗传学会微生物遗传专业委员会委员，中国农业生物技术学会理事，中国生物物理学会肠道菌群分会理事，国际期刊《Frontiers in Cellular and Infection Microbiology》Associate Editor，《AEM》、《Stress Biology》等期刊编委。

代表性文章(*为通讯作者)：

1.Song L^#, Pan J^#, Yang Y^#, Zhang Z, Cui R, Jia S, Wang Z, Yang C, Xu L, Dong TG, Wang Y*,Shen X*.Contact-independent killing mediated by a T6SS effector with intrinsic cell-entry properties.Nat. Commun.,2021, 12(1):423. (Editor’s Highlights)

2.Zhu L^#, Xu L^#, Wang C^#, Li C, Li M, Liu Q, Wang X, Yang W, Pan D, Hu L, Yang Y, Lu Z, Wang Y, Zhou D*, Jiang Z*,Shen X*.T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese.PNAS, 2021;118(42):e2103526118.

3.Li C^#, Zhu L^#, Wang D^#, Wei Z, Hao X, Wang Z, Li T, Zhang L, Lu Z, Long M, Wang Y*, Wei G*,Shen X*.T6SS secretes an LPS-binding effector to recruit OMVs for exploitative competition and horizontal gene transfer.ISME J,2021, Online ahead of print.

4.Zhang L^#*, Li S^#, Liu X, Wang Z, Jiang M, Wang R, Xie L, Liu Q, Xie X, Shang D, Li M, Wei Z, Wang Y, Fan C, Luo ZQ*,Shen X*.Sensing of autoinducer-2 by functionally distinct receptors in prokaryotes.Nat. Commun.,2020, 11(1):5371. (Editor’s Highlights)

5.Jinshui Lin^#, Weipeng Zhang^#, Juanli Cheng, Xu Yang, Kaixiang Zhu, Yao Wang, Gehong Wei, Pei-Yuan Qian, Zhao-Qing Luo andXihui Shen*.APseudomonasT6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition.Nat. Commun.,2017, 8:14888

6.Meiru Si, Chao Zhao, Brianne Burkinshaw, Bing Zhang, Dawei Wei, Yao Wang, Tao G. Dong* and Xihui Shen*. Manganese scavenging and oxidative stress response mediated by the type VI secretion system inBurkholderia thailandensis.PNAS,2017, 114(11):E2233-E2242.(cited by Faculty of 1000 Prime)

7.Si M^#, Wang Y^#, Zhang B, Zhao C, Kang Y, Bai H, Wei D, Zhu L, Zhang L, Dong TG,Shen X*. A type VI secretion system engages a redox-regulated dual functional heme transporter for zinc acquisition.Cell Rep.,2017, 20:949-959